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Biomarker discovery for lysosomal storage disorders using a metabolomic approach

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Join us to learn how to perform untargeted/semi-targeted metabolomic studies to discover novel biomarkers by mass spectrometry

1 Sept 2020
Georgina Wynne Hughes
Editorial Assistant

Expert insights

Dr. Michel Boutin, Technical Director of the Waters-CHUS Expertise Centre in Clinical Mass Spectrometry
Dr. Michel Boutin, Technical Director of the Waters-CHUS Expertise Centre in Clinical Mass Spectrometry

High-accuracy mass spectrometry is a powerful tool to discover biomarkers, allowing the diagnosis, monitoring and follow-up of different diseases. During this webinar, Dr. Michel Boutin, Technical Director of the Waters-CHUS Expertise Centre in Clinical Mass Spectrometry, will discuss the different steps of untargeted/semi-targeted metabolomic studies, such as sample collection, sample preparation, sample analysis, data analysis and structural elucidation, along with strategies to bypass potential pitfalls.

Different tools to structurally elucidate targeted biomarkers will also be discussed and examples of metabolomic studies that led to the discovery of new biomarkers for genetic diseases will be presented.

Register here

Key learning objective:

  • Learn how to perform untargeted/semi-targeted metabolomic studies to discover novel biomarkers by mass spectrometry.

Who should attend?

  • Clinical scientists, medical technologists & biomedical scientists
  • Decision makers interested in tools to advance biomarker discovery
  • Clinical researchers with an interest in analytical method development
  • Clinicians with an interest in inborn errors of metabolism
  • Post-doctoral and postgraduate scientists with an interest in analytical method development

Certificate of attendance

All webinar participants can request a certificate of attendance, and a learning outcomes summary document for continuing education purposes.

Choose between two sessions of this webinar:

  • Session 1 - Tuesday, September 22 at 16:00 BST / 11:00 EDT / 08:00 PDT / 17:00 CEST
  • Session 2 - Wednesday, September 23 at 09:30 IST / 12:00 CST / 13:00 JST

Register for this webinar here>>

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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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