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BioFocus DPI releases five new compound libraries

7 Apr 2008

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BioFocus DPI today introduces new FieldFocus and SoftFocus libraries that were created with advanced modeling tools. The libraries consist of novel drug-like compounds specifically targeted towards kinases and voltage-dependent ion channels. These targets represent two of the most important and commonly studied protein classes for drug discovery. Two new lead-like ThemePair Fragment libraries from BioFocus DPI are also being released.

Following the success of the FieldFocus ion channel libraries, BioFocus DPI is introducing its first FieldFocus kinase (FFK) libraries. The FFK01 and FFK02 libraries have been designed using a new in silico, fragment-based approach to tackle kinase library design from a ligand perspective, complementing the highly successful SoftFocus kinase libraries.

BioFocus DPI is also releasing its latest SoftFocus ion channel (SFI) library. SFI08 contains approximately 500 compounds designed to target voltage-dependent ion channels. These libraries were created using BioFocus DPI’s proprietary chemogenomic tool Helical Domain Recognition Analysis, which has been proven to generate potent and selective hit series.

Two new ThemePair Fragment (TPF) libraries are also now available from BioFocus DPI. The TPF10 library contains lead-like compounds substituted with a single heavy atom and are designed for use in X-ray crystallographic screening. The TPF11 library is based on nine bicyclic scaffolds suitable for both conventional bioassays as well as high-throughput affinity screening.

“We are constantly evolving the design tools used in the production of our focused libraries and the latest FieldFocus kinase libraries are an exciting new addition to our portfolio,” said Richard Hill, Director Discovery Products, BioFocus DPI.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process.  Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Protein CrystallographyProtein crystallization is the process of crystallizing purified proteins for 3D structure analysis by x-ray crystallography. The main methods of protein crystallization include sitting drop, hanging drop and microbatch. It is important to control parameters such as pH, temperature and concentration. Following crystallization, detectors and software are used for data collection and analysis.

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BioFocus DPI releases five new compound libraries