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BioFocus DPI launches ‘Intelligent Screening’ platform at SBS

6 Apr 2008

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BioFocus DPI is launching a new approach to discovery biology at the Society for Biomolecular Sciences Annual Conference taking place this week in St. Louis. Called ‘Intelligent Screening’, this approach focuses on combining the know-how and expertise of BioFocus DPI’s scientists with extensive high-throughput and information-rich screening capabilities to generate faster results and accelerate partners’ drug discovery programs.

According to Dr. Katherine Hilyard, Vice President of Biological Sciences at BioFocus DPI: “As the name Intelligent Screening implies, we are promoting an intelligence-led approach to discovery biology. This means harnessing our considerable screening experience within a wide range of target classes and disease areas to develop customized, biologically-relevant assays for partners’ discovery programs. This is in contrast with alternative approaches such as running numerous high-volume, high-throughput tests where the likelihood of identifying compounds with the desired biological activity is low.”

In shaping its Intelligent Screening approach, BioFocus DPI calls upon: PrimePath™, its compound screening service that uses disease-relevant complex assays in human primary cells; its high-throughput and information-rich ion channel screening capabilities; and its natural product screening platform, which is ideal for addressing difficult targets, such as protein-protein interactions. Furthermore, these services are complemented by BioFocus DPI’s world-class screening libraries.

More information about using this Intelligent Screening approach in hit finding, hit-to-lead and lead optimization campaigns can be found via the article webpage.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process.  Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Compound AnalysisCompound analysis is used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds have the desired effect, such as interaction with a target protein, during high throughput screening.

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BioFocus DPI launches ‘Intelligent Screening’ platform at SBS