BioFocus DPI launches ADME/PK service and software platform

19 Feb 2008

Product news

BioFocus DPI, a leading provider of gene-to-preclinical discovery services, announces the launch of ADME/PK Laboratory and the StarDrop™ software platform.

ADME/PK Laboratory is the new name for the expanded BioFocus DPI ADMEnsa Laboratory service. In addition to providing high-quality in vitro services backed by expert consultancy, ADME/PK Laboratory extends beyond early ADME to incorporate in vivo pharmacokinetics and bioanalysis. These capabilities provide key information to interpret a new drug’s potential for achieving the required ADME profile in man.

The new StarDrop (structure-activity relationships for drug optimization) software suite is an upgrade to BioFocus DPI’s ADMEnsa Interactive package. StarDrop has been expanded beyond the prediction of ADME properties to include interactive data visualization and compound modeling for effective decision making. Its unique compound prioritization capabilities integrate in silico predictions with in vitro and in vivo data to enable the design, prioritization and selection of compounds with an optimal balance of properties at every stage of drug discovery.

“With the launch of ADME/PK Laboratory we are pleased to offer customers a full range of in vitro and in vivo services that can be tailored to meet the specific needs of a discovery program,” said Matthew Segall, BioFocus DPI’s Senior Director ADMET. “Through StarDrop, we aim to facilitate effective decision making by creating an intuitive environment for the design and identification of compounds that are likely to succeed in downstream drug discovery and development.”

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Integration ServicesIncorporate lab systems, software and equipment with integration services.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.
BioFocus DPI launches ADME/PK service and software platform