BIOCIUS Life Sciences Expands Contract Research Service with New ADME Assay Analysis

5 Jan 2011
Sarah Sarah
Marketing / Sales

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BIOCIUS Life Sciences Inc. announces a new contract research service that expands the in vitro ADME (Absorption, Distribution, Metabolism and Excretion) assays that can be analyzed quickly and efficiently using RapidFire technology. The extension of the existing CYP Inhibition service now includes analysis of a wide range of assays including microsomal stability, permeability and plasma protein binding. Additionally, BIOCIUS will offer custom services for the development of analysis methods for other ADME assays.

“Our 3 day data turnaround guarantee greatly enhances laboratory efficiency, providing an advantage in the competitive drug discovery market,” said William LaMarr, PhD, Vice President of Research and Contract Services at BIOCIUS. “With all the issues facing the biopharmaceutical industry today, outsourcing has become an important strategy – our expanded contract research solutions enable researchers to obtain results faster and more efficiently, without changing their existing protocols and workflows.”

ADME analysis, a step in the drug discovery process where candidate compounds are evaluated for their safety and suitability as pharmaceuticals, is often a bottleneck for drug discovery researchers. The ADME assay analysis service from BIOCIUS enables clients to preserve their assay method integrity as assays are processed using their own laboratory methods and then analyzed at BIOCIUS using RapidFire mass spectrometry technology. RapidFire processes samples at speeds of up to six seconds per sample, enabling unprecedented throughput and data turnaround not possible using other methods.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.