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Bio-Rad Launches New Anti-tTG Assays for Celiac Disease

Bio-Rad
17 Apr 2006

Product news

Bio-Rad Laboratories, Inc., a multinational manufacturer and distributor of clinical diagnostics products and leader in autoimmune testing, announced today the launch of anti-tissue transglutaminase (tTG) assay IgA and IgG assays for celiac disease. The new assays are FDA-cleared, CE-marked and automation-ready.

The Bio-Rad anti-tTG assay is a solid phase enzyme immunoassay for the semi-quantitative and qualitative detection of antibodies against tissue transglutaminase (tTG) in human serum. Each assay contains 12 eight-well breakaway ELISA strips for economy of use, pre-diluted calibrators for flexible quantitative and qualitative calibration, color-coded reagents and reagent bottles for ease of use. Each assay is designed to be easily adaptable on an automation platform. The new assays share the common protocol with other Bio-Rad autoimmune EIA assays.

Celiac disease is one of the most common, lifelong disorders in the western countries. It is characterized by immune-mediated damage to the jejunal mucosa of the gastrointestinal tract that is triggered by gluten, a protein found in wheat, rye and barley. Due to its wide spectrum of clinical symptoms, celiac disease is often misdiagnosed or under-diagnosed.

Bio-Rad anti-tTG assays are new generation of anti-tTG kits with increased sensitivity and specificity for celiac disease diagnosis. More celiac patients will be identified when screening with the Bio-Rad tTG assays, giving clinical laboratories more confidence in their testing results and providing a better outcome for the patients.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.

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Bio-Rad Launches New Anti-tTG Assays for Celiac Disease