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Bio-Rad Introduces the Lucid ID Access Pack to Complete Top-Down Biomarker Discovery Workflow

Bio-Rad
20 Jul 2009
Sarah Sarah
Marketing / Sales

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Bio-Rad Laboratories, Inc., a multinational manufacturer and distributor of life science research and clinical diagnostic products, today announced the launch of the Lucid??ID Access Pack, the first product designed for the Lucid Proteomics System?? a proteomics solution in development by Bio-Rad and Bruker Corporation that will combine Bio-Rad?? ProteinChip? surface-enhanced laser desorption/ionization (SELDI)-based array technology with Bruker?? ultrafleXtreme MALDI-TOF/TOF mass spectrometer, enabling researchers to use both top-down and bottom-up proteomics approaches for biomarker discovery on the same system. With the Lucid ID Access Pack, researchers who currently profile their biomarkers using Bio-Rad?? ProteinChip? array technology can use the Lucid ID Access Pack to complete the biomarker purification process and identify these biomarkers with high confidence.

A distinct advantage of the Lucid ID Access Pack is the ability to identify peptides under 4 kilodaltons directly on a ProteinChip array after a simple, one-step enrichment. Identification of proteins and peptides over 4 kilodaltons that require trypsin digestion is demystified by following Bio-Rad?? Biomarker Purification and Identification Guide and by using ProteinChip arrays in conjunction with Bruker?? ultrafleXtreme MALDI-TOF/TOF, which has been optimized for the ability to read ProteinChip arrays. This new high-performance system delivers the resolution required for rapid, high-confidence protein identification. For convenience, the Lucid ID Access Pack is also backwards-compatible with other Bruker autofleX and ultrafleX MALDI TOF/TOF systems.

The Lucid ID Access Pack contains the essential accessories and consumables needed for high-confidence identification of putative biomarkers, including:

??A chip holder specifically designed to analyze ProteinChip arrays on the Lucid Proteomics System

??ProteinChip arrays with chromatographic surfaces most commonly used in identification protocols

??A manual including optimized instrument settings for on-chip peptide identification

??All necessary user licenses

??Personalized consulting with premier experts on purification and enrichment strategies


About the Lucid Proteomics System

The Lucid Proteomics System combines and refines surface-enhanced laser desorption/ionization (SELDI) from Bio-Rad and time-of-flight (TOF/TOF) technologies from Bruker, enabling both top-down and bottom-up proteomics approaches for biomarker discovery on one system. The system offers new solutions for protein biomarker discovery, in particular, high-throughput profiling and high-confidence identification of intact peptides and proteins under 30 kilodalton, which are challenging for current technologies to identify.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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