Bio-Rad Expedites Disease Biomarker Discovery and Drug Development with Launch of Bio-Plex Pro Human Cytokine Screening Panel

Bio-Rad Laboratories, Inc. has announced the launch of the Bio-Plex Pro Human Cytokine Screening Panel, the first validated high-performance multiplex assay on the market. The panel can identify and quantify 48 different analytes linked to heart disease, autoimmunity and allergy, cancer, and many other conditions.

“The Bio-Plex Pro Human Cytokine Screening Panel has been validated to deliver more accurate data points within assay range than similar multiplex assays on the market,” said Ivan Huang, Bio-Rad Global Product Manager, Bio-Plex. “The ability to accurately probe both endogenous and diseased/treated samples with a single assay across a broad range of targets gives researchers tremendous insight and enables them to make actionable decisions in terms of biomarker discovery and drug development.”

To understand complex biological networks, disease states, and treatment effects, biopharma and academic researchers need to simultaneously interrogate many biomarkers present in human samples. The Bio-Plex Pro Human Cytokine Panel enables highly sensitive detection of the most often researched and biologically relevant cytokines in a single well, conserving time and resources. This panel consists of adaptive immunity cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines all in a single well.

The assay provides highly sensitive detection — well below sub-picogram per milliliter range — without adding amplification steps to the workflow. The antigens and antibodies are also carefully developed in-house and tested to maximize specificity and minimize signal interference from irrelevant molecules, to enable precise and accurate quantification of multiple analytes simultaneously.

Other key benefits:

• Reproducible results — gain confidence in experiments with a robust, magnetic bead–based workflow
• Save time — the entire immunoassay can be run in less than 4 hours as opposed to other multiplex panels, which can require overnight incubation

The Bio-Plex Pro Human Cytokine Screening Panel is a ready-to-use, 1 x 96-well kit that includes premixed magnetic capture beads and detection antibodies, multiplexed standards and controls, secondary antibodies for fluorescence detection, and buffers. It is compatible with the following platforms: Bio-Plex MAGPIX Multiplex Reader, Bio-Plex 200 and Bio-Plex 3D Multiplex Immunoassay Systems, LX200 Instrument, and Flexmap 3D System. Data can be managed and analyzed using Bio-Plex Manager and Bio-Plex Data Pro Software.

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