Bibby Scientific’s Integrity 10 Reaction Station Accelerates Drug Development

29 Jun 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

Analytical scientists at the University of Lincoln’s School of Pharmacy are accelerating their drug development research thanks to Bibby Scientific’s Integrity 10 Reaction Station, which enables different reactions to be performed simultaneously with varied process conditions. Bibby’s Reaction Stations are designed for screening and optimizing ten different reactions in parallel across individually controlled units for applications including solubility and protein crystallization.

The Integrity 10 Reaction Station offers precise control of temperature and stirring speed for each individual reaction, for sample volumes ranging from 1 - 25 mL and temperatures ranging from -30°C to 150°C. It is easily operated with a color touchscreen and has accessories including multi-infrared probes, and attachments for refluxing and working under inert conditions.

“The Integrity 10 is perfect for my research because I’m trying to crystallize problematic compounds, so I need to change a lot of parameters for each experiment,” said Paul Stainton, PhD student at the University of Lincoln. “The Reaction Station is helping to move my research along much more quickly, because it allows me to perform ten different experiments simultaneously with different parameters.”

Running simultaneous reactions not only saves valuable time, materials and labor, but can also generate more comparable and higher quality scientific data.

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Protein CrystallographyProtein crystallization is the process of crystallizing purified proteins for 3D structure analysis by x-ray crystallography. The main methods of protein crystallization include sitting drop, hanging drop and microbatch. It is important to control parameters such as pH, temperature and concentration. Following crystallization, detectors and software are used for data collection and analysis.Reaction MonitoringTouchscreenProcess OptimizationProcess optimization involves improving the efficiency, cost-effectiveness, and quality of processes in various industries, including manufacturing, pharmaceuticals, and biotechnology. Explore process optimization solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.CrystallizationCompound ScreeningCompound screening is a method used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds interact with the target protein during screening and could therefore be carried forward in the drug development process.