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Azenta Life Sciences expands fleet of PacBio HiFi sequencing systems

Azenta Life Sciences

PacBio’s Sequel IIe devices will support genomic researchers around the world

7 Jan 2022
Dora Wells
Clinical Content Editor

Industry news

PacBio has announced an expansion of its extensive suite of HiFi applications with Azenta Life Sciences, formerly GENEWIZ. The deal will increase PacBio’s HiFi sequencing platforms across Azenta’s newly combined company and support Azenta’s mission to enable life science companies to deliver impactful breakthroughs and therapies to market faster.

PacBio’s HiFi sequencing technology uniquely combines the benefits of high accuracy with long read lengths, providing a comprehensive view of genomes and transcriptomes to scientists tackling complex genetic challenges. Azenta’s expanded investment in HiFi sequencing signifies the technology’s ability to unlock invaluable insights for researchers in academia, pharma, and biotech.

"Azenta is a global leader in genomics services, and we’re very pleased that our highly accurate HiFi sequencing technology will continue to underpin leading-edge research to build a healthier world for people everywhere," said Christian Henry, CEO at PacBio. "With a focus on the future, we are continuing to redefine what is possible in genomics."

With more than 20 years of experience specializing in DNA and RNA sequencing and synthesis services, working with over 6,000 institutions worldwide, Azenta is using PacBio Sequel IIe technology to offer enterprise-wide sample exploration and management solutions across the drug development pipeline.

"We are excited to significantly increase our capacity by offering a best-in-class long-read sequencing platform supporting customers through our unique solutions spanning broad genomics applications," said Ginger Zhou, vice president and general manager at Azenta Life Sciences. "The new Sequel IIe platform, in combination with our team of scientific experts, will enable our diverse customer base to obtain actionable data faster."

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Sequel System

Pacific Biosciences

The new Sequel System is based on Pacific Bioscience’s proven Single Molecule, Real-Time (SMRT) technology and delivers about 7X more reads with 1 million zero-mode waveguides (ZMWs) per SMRT Cell. The Sequel System is ideal for projects such as rapidly and cost-effectively generating high-quality whole genome de novo assemblies. This innovative sequencing system features automated reagent and SMRT Cell handling and an integrated software suite.   The Sequel System has two primary user access points: Sequel touchscreen interface (for initiating and monitoring runs) Sequel workdeck (for loading samples, SMRT Cells, reagents, and disposables)   Features: Intuitive run setup and monitoring tools Run-time flexibility (from 30 minutes to 6 hours per SMRT Cell) Run-size flexibility (from 1 to 16 SMRT Cells per run) Robotic workflow management  

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PACBIO RS II

Pacific Biosciences

The PacBio RS II is a Single Molecule, Real-Time (SMRT®) DNA Sequencing System that provides the highest consensus accuracy and longest read lengths of any available sequencing technology. SMRT Sequencing is ideal for de novo assembly, characterization of genetic variation, methylation analysis, microbiology studies, and more.The instrument features high performance optics, automated liquid handling, and an environmental control center, all directed through an intuitive touchscreen interface. The computational brain responsible for primary data analysis, called the Blade Center, is also included. This allows for seamless integration of performance enhancements through chemistry and software advances.Features: Intuitive run setup tools Workflow optimization tools Error-proof instrument loading Robotic workflow management Run size flexibility – from 1 to 16 SMRT Cells per run Applications: Genome finishing Epigenetics Haplotype phasing Repeat expansions Isoform sequencing Minor variants

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DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.RNARNA is a nucleic acid that plays a key role in gene expression and protein synthesis. It serves as a messenger between DNA and ribosomes, carrying genetic instructions to produce proteins. Advances in RNA-based therapies, such as mRNA vaccines and gene editing, have revolutionized treatment strategies for genetic disorders and infectious diseases. Explore RNA research tools and therapies in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.GenomicsGenomics is the study of genomes, focusing on the sequencing, analysis, and interpretation of genetic material. It is key in understanding genetic diseases, evolutionary biology, and personalized medicine. Techniques like next-generation sequencing (NGS) are commonly used in genomics research. Browse our peer-reviewed product directory to find the best genomics tools, compare products, check reviews, and get pricing directly from manufacturers.Genome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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Azenta Life Sciences expands fleet of PacBio HiFi sequencing systems