Automation Software for Walk-Away Hydrogenation

15 Mar 2007

Product news

Control software specialists Aitken Scientific have concluded an agreement for ThalesNano to licence bespoke software for its recently launched H-Cube™ Autosampler system.

Aitken Scientific were approached to develop the proprietary software as a result of their proven reputation for creating successful client partnerships with a wide range of science and technology companies. By integrating the standalone H-Cube hydrogenation reactor with a Gilson GX-271 liquid handler, the H-Sampler software automates hydrogenation reactions for high throughput synthesis of compound libraries in pharmaceutical development.

The wizard-driven software provides an easy to use interface, which now allows up to 100 samples to be processed a day at different temperatures, pressures, and flow rates. With automated sample injection and fraction collection the entire sequence can be left unattended and supervised by the software. Existing users of the H-Cube reactor can readily expand their system by adding the liquid handler and fully supported H-Sampler software.

Aitken Scientific’s expertise in software design combined with ThalesNano’s innovative technology and Gilson’s proven liquid handling instrumentation has produced a revolutionary automated hydrogenation platform. The result of streamlining and simplifying this complex process now allows hydrogenation to be integrated as the final step in automated compound library synthesis along with reaction optimisation and catalyst screening.

Links

Tags

AutosamplersAutosamplers are automated sample loaders used with a number of separation and analytical techniques. HPLC autosamplers use automated partial or full-loop injection systems and place samples in vials or microplates for analysis. Autosamplers can also be used for elemental analysis. Features to consider include repeatability, syringe capacity, footprint and temperature controls.  Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process.  
Automation Software for Walk-Away Hydrogenation