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Applied Biosystems/MDS Sciex mass spectrometer cuts costs for routine therapeutic drug monitoring

Thermo Fisher Scientific
28 Feb 2006

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Scientists from the Department of Clinical Chemistry at the George August University, Germany, are using an Applied Biosystems/MDS Sciex API 2000™ LC/MS/MS System to research and develop methods for routine therapeutic drug monitoring.

Prof Dr Michael Oellerich, Head of the Department of Clinical Chemistry, explained: "We started using this system over six years ago, when we developed a very elegant tandem MS method for the simultaneous determination of various immunosuppressive drugs such as sirolimus, everolimus, tacrolimus and cyclosporin in whole blood. It is also used for determination of total and free plasma concentrations of mycophenolic acid and its metabolites in pharmacokinetic studies."

"I am very happy with the API 2000 System; it is robust and reliable and we have practically no relevant down time with our two systems. Using LC/MS/MS, we can simultaneously determine several compounds and we have a sufficient throughput with at least 50 per cent fewer direct costs! Furthermore, we can work with very low limits of quantification, with very high precision and specificity, far better than immunoassays. We are always refining the process, for example, we are now using solid phase extraction with the big advantage that there is less ion suppression. This means we can shorten the run time dramatically, from 4 minutes to about 2 minutes."

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.

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Applied Biosystems/MDS Sciex mass spectrometer cuts costs for routine therapeutic drug monitoring