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Antiverse collaborates with a top 20 pharma company to identify antibody drug candidates using AI Augmented Drug Discovery platform

Antiverse

The project demonstrates the potential of Antiverse’s platform to reduce time and costs associated with antibody drug discovery

31 Jan 2022
Lee Haines
Administrator / Office Personnel

Industry news

Antiverse, a biotechnology company developing a computational antibody drug discovery platform, has announced a partnership with a top 20 pharma company with core competencies in the life science fields of health care and nutrition. The collaboration has been successful in identifying antibody candidates for a target of interest, with greater diversity (2.3x) and accuracy compared to alternative bioinformatics pipeline selection methods.

Using Antiverse’s proprietary AI-Augmented Drug Discovery platform, 248 sequences were identified, of which over 230 were antibody binders. Five of these antibody candidates were found to be cross-reactive.

Antiverse is combining machine learning and phage display techniques to model antibody-antigen interactions. The current version of the platform uses next generation sequencing and AI to provide diverse antibody candidates for any given target. The technology is being developed to enable the development of drugs for “difficult” targets associated with cancer, heart, and lung diseases. The platform will overcome limitations commonly associated with traditional screening including overcoming amplification bias which leads to diversity loss and selection bias which results in the loss of unique antibodies.

Murat Tunaboylu, Chief Executive Officer of Antiverse, said: “We are pleased to collaborate with a top 20 pharma company on this discovery project. Our AI-powered antibody drug discovery platform successfully identified more binders with better diversity to state-of-the-art high-throughput colony picking and bioinformatics pipeline selection. Researchers can find more diverse antibodies by unlocking the full potential of their library/discovery process with our AI-augmented discovery platform and through our fee-for-service offering, we hope to partner with other biotech and pharma companies on projects to identify other challenging targets.”

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.Antibodies

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