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Anti-Osteoclast-Associated Receptor (OSCAR)-PE RUO Monoclonal Antibody Expands Study of Dendritic Cell Functions

Beckman Coulter Diagnostics
27 Sept 2006

Product news

Beckman Coulter, Inc. introduces the IOTest® Anti-OSCAR-PE conjugated monoclonal antibody. In humans, the OSCAR antigen is expressed on osteoclasts, which are involved in bone development and remodeling, and on myeloid dendritic cells, among others.

OSCAR is the first FcRγ-associated molecule described on human myeloid dendritic cells. It is an activating molecule involved in antigen capture and presentation that may modulate the response of both innate and adaptive immunity. With the new Anti-OSCAR-PE Monoclonal Antibody, researchers can tag a new antigen that is thought to be implicated in the tolerogenic function of dendritic cells.

Beckman Coulter is the leader in dendritic cell (DC) reagents, and the new anti-OSCAR-PE antibody completes the company’s extensive line of DC markers. This directly conjugated monoclonal antibody, coupled with other markers, is useful in identifying the expression/ regulation of new antigens on dendritic cells by flow cytometry.

“If the induction of tolerance by dendritic cells is well known, especially when they process self antigens, study of the molecular basis behind this phenomenon may help to understand its deregulation in cancers and autoimmune diseases,” commented Michel Pagniez, cellular analysis product manager for Beckman Coulter.

The preformulated, standardized IOTest Anti-OSCAR-PE monoclonal antibody is provided in 100-test vials. Beckman Coulter offers a number of reagents, controls and markers that can be used with this new antibody. Anti-OSCAR-PE is approved for research use only.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

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