AnalytiCon Discovery to present concept of Biology Oriented Synthesis (BIOS) at SBS - Booth #2323

AnalytiCon Discovery provides two main product lines for its off-the-shelf compound libraries NATx and MEGx. The NATx libraries are biologically targeted synthetic compounds created by applying our Biology Oriented Synthesis (BIOS) and the MEGx collection represent pure natural products with fully elucidated structures.

We would like to acquaint you with AnalytiCon's concept of Biology Oriented Synthesis (BIOS), recently published in PNAS (http://www.pnas.org/cgi/content/abstract/103/28/10606). The use of natural product building blocks to create biologically prevalidated starting points for library synthesis as well as fully synthetic templates inspired by natural molecules sprout three dimensional arrangements of pharmacophores which explicitly do not belong to all these well researched privileged structures. Thus "BIOS employs the core structures of compound classes that are relevant to nature as guiding scaffolds for the design and synthesis of compound collections for chemical biology and medicinal chemistry research". This translates into a stringent and rapid strategy to discover new inhibitor classes, e.g. in oncology (Cdc25a, SHP2), in metabolic diseases (PTP1B) and in anti-infectives (MptpA and MptpB).

Besides its broad portfolio (modern custom synthesis, natural product based drug development programs, chemodiversity profiling, separation, isolation and structure elucidation), AnalytiCon has medicinal chemistry and computational chemistry in place and could act as a one-stop-shop for you based on but not limited to natural products.

Please stop by our booth #2323 to explore the possibilities we can offer to you.

AnalytiCon will deliver a presentation on Monday September 18th, Session 1A in Ballroom 6A starting at 3:20 PM about this topic. This presentation will be given by our Lars Haustedt and is titled: Biology-Oriented Synthesis: Natural Product Based Discovery of Novel Enzyme Inhibitors.

Additional information is available through the article webpage.