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Affymetrix Releases Axiom™ Genome-Wide CHB 1 Array

Affymetrix, Inc.
11 Apr 2011
bridget bridget
Laboratory Director

Product news

Affymetrix, Inc. today announced the expansion of its Axiom product line with the launch of the Axiom™ Genome-Wide CHB 1 Array, the first commercial product to maximize genetic coverage of common alleles in Han Chinese populations. This array is the third population-designed array for the Axiom™ Genotyping Solution and one of several additional arrays commercialized this year.

The Axiom Genome-Wide CHB 1 Array is a powerful tool for characterizing the genetic basis of disease and studying disease associations in Han Chinese populations. To design the array, researchers at the Bio-X Center of Shanghai Jiao Tong University and Beijing’s Fuwai Hospital took advantage of more than 10 million validated markers in the Axiom Genomic Database, including content drawn from the 1000 Genomes Project, as well as Han Chinese data made available through the International HapMap Project. The Axiom Genome-Wide CHB 1 Array has proven so successful in customer studies that Affymetrix fully commercialized it so other researchers could benefit from studies using this array.

“We are very happy with the performance of the Axiom CHB Array,” said Dr. Yong Yong Shi, Associate Professor and Group Leader in the Nutrition & Health Research Base, Bio-X Center of Shanghai Jiao Tong University in Shanghai, China. “We knew a population-optimized approach would offer more power to detect disease associations. This has been confirmed by the fact that we’ve already found several novel associations with hypertension that we are currently validating and we hope to publish our findings before the end of the year.”

The Axiom Genome-Wide CHB 1 Array optimizes genomic coverage of common alleles from the Han Chinese genome. Compared to competing arrays with a similar number of markers, it has the highest coverage of variants in important biological categories such as the National Human Genome Research Institute (NHGRI) Catalog of Published Genome-Wide Association Studies, Sanger Cancer Genome Census genes, MHC genes, cardiovascular genes, and immune and inflammation pathway genes. The array also offers coverage across chromosomes X and Y, the mitochondrial genome, and drug metabolism genes (ADMET).

“Our Axiom Genome-Wide Arrays allow researchers to better match cases and controls within ethnic groups so they focus only on differences by disease state, not structural differences between populations," said Andy Last, Chief Commercial Officer at Affymetrix. "The Axiom Genome-Wide CHB 1 Array is ideally suited to customers interested in exploring the genetic complexities underlying disease in Han Chinese populations and in populations of Chinese descent.”

The complete Axiom Genotyping Solution consists of a suite of population-designed array plates, the new Axiom 2.0 Reagent Kit, an automated target preparation station developed jointly by Affymetrix and Beckman Coulter, the GeneTitan® Instrument, and new Genotyping Console™ Software 4.1 for automated allele calling and quality control. The GeneTitan Instrument integrates a hybridization oven, fluidics processing, CCD imaging device, and analysis software for maximum data reproducibility, user productivity, and scalability. Scientists can run more than 760 samples per week with only one full-time technician and minimal user intervention, which is a significant advantage over competing products.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Affymetrix Releases Axiom™ Genome-Wide CHB 1 Array