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Advion Releases Chip-Mate, a Chip-Based Nano-LC Ion Source for Mass Spectrometers

Advion Interchim Scientific
11 Dec 2013
Sarah Thomas
Associate Editor

Product news

Advion, Inc., a leading instruments and consumables developer for the life sciences industry, has announced the release of the latest in chip-based technology, the Chip-Mate™. The Chip-Mate is an ESI Chip®-based nano-LC ion source for applications requiring small micron ID HPLC columns and nanoelectrospray ionization (nano-ESI). This latest product offering from Advion is a line extension of its well-established TriVersa NanoMate® technology.

While the TriVersa NanoMate has multiple modes of operation, the Chip-Mate is an easy-to use nano-LC ion source that focuses on stable and reliable nano-ESI through its ability to sense poor spray performance and engage the next nozzle. Ease-of-use and robustness of nano-ESI are important features for proteomics customers as well as applications in highly regulated environments such as biomarker/biosimilar and small molecule quantification utilizing nano-LC.

For use with the Chip-Mate, Advion has created a smaller footprint ESI Chip with 25 emitter nozzles and an integrated memory card. In combination with spray sensing and next nozzle capability, researchers can now have complete confidence for 24/7 nano-LC/MS/MS operation.

“Advion is known for its fit-for-purpose products and creating instrumentation that eases challenging workflows. This latest development offers the established benefits seen with chip-based nanoelectrospray in a package just for nano-LC users,” notes Simon Prosser, Vice President of Marketing. “We have long anticipated this product introduction, and given the advancements in nano-LC and proteomics, we believe this is the optimal time to offer this product to the market.”

Compatible with Thermo Fisher model mass spectrometers, including the LTQ, Orbitrap, Fusion, Exactive TSQ, etc., the Chip-Mate is now available for shipment with first units shipping this month to customers in Europe, the US and South America. Chip-Mate is available worldwide through a global network of distributors committed to innovative technology and exceptional customer service.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.NanoLCNano LC is a nano scale liquid chromatography technique typically used for proteomic applications. The nano refers to the very low flow rate of the mobile phase in the system. The advantage of nanoLC is its high sensitivity. Often the system is integrated with a mass spectrometer in nano LC-MS or nano LC-MS/MS. When using nanoLC equipment consider column choice, software and accurate and precise flow rate control.BiosimilarsBiosimilars are very similar versions of approved and authorized medicines. Clinically inactive components will have minor differences, but there are no significant differences between the biosimilar and the original product in terms of potency, purity and safety.

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Advion Releases Chip-Mate, a Chip-Based Nano-LC Ion Source for Mass Spectrometers