Advance your drug discovery and development with improved drug screening, imaging, and characterization
Explore exclusive interviews and the latest resources to support your drug discovery workflows, from chemical imaging and fragment screening to assay development and gene therapy
19 Apr 2021
Edward Carter
Publishing / Media
Editorial article
For this new special feature, we’ve pulled together a selection of the top new resources to support and advance your work in drug discovery. Find out how next-generation fragment screening can streamline biophysical research, learn the pros and cons of flow imaging microscopy, discover how to achieve your compound's optimal druggable potential, and much more.
CHEMICAL IMAGING:Clarity and speed to make informed, faster decisions
In this eBook, discover how the Agilent 8700 Laser Direct Infrared (LDIR) chemical imaging system provides a simple highly automated approach for obtaining reliable high-definition chemical images.
CYTOTOXICITY: Increase MTT cell proliferation assay throughput
In this guide, see how conducting MTT assays with the INTEGRA Biosciences ASSIST PLUS pipetting robot offers a simple, fast and cost-effective solution for assessing cellular metabolic activity.
SCREENING: Pushing the boundaries of fragment-based drug design
In this presentation, hear how next-generation fragment screening can streamline biophysical research, including the benefits of Malvern Panalytical's automated ITC workflow and other techniques.
POSTER: Top tips for discovery and development of novel compounds
This poster by Buchi provides tips to help you develop reliable high-throughput methods to identify promising compounds as quickly and accurately as possible, as well as solutions for development workflows.
NEW eBOOK: Ultimate guide to flow imaging microscopy for protein therapeutics
Learn the pros and cons of flow imaging microscopy and how it compares to other particle analysis methods for characterizing proteins and subvisible particles, in this eBook by Yokogawa Fluid Imaging Technologies.
ASSAY: Targeting kinases involved in the innate immune response
Learn how the BellBrook Labs Transcreener ADP2 Kinase Assay allows rapid assay development to enable screening and dose-response measurements for multiple kinases involved in innate immunity.
CHARACTERIZATION: Are you advancing the best version of your compound?
Learn how Charles River Laboratories' Drug Discovery Services can help you achieve your compound's optimal druggable potential through studies that provide vital data to minimize toxicity and maximize efficacy.
SCREENING & SELECTION: Why chemistry-led design brings the greatest value
In this guest article by LGC, learn how the application of organic chemistry in screen design, analysis and interpretation of results is powerful in creating efficient screens, optimized forms and positive recommendations.
GENE THERAPY: How to design MOA reflective cell-based potency assays
In this downloadable case study, learn how Svar Life Sciences' iLite® cell-based reporter gene assays can help meet the analytical challenges of creating bioassays for gene therapy projects.
WEBINAR SERIES: Drug Discovery & Development
Hear from experts on the latest techniques and technologies helping researchers advance their drug discovery and development workflows. Plus, discover your Scientists’ Choice Awards winners.
YOUR WINNERS: Drug Discovery & Development Scientists' Choice Awards
The annual Scientists' Choice Awards celebrate the industry’s top technological innovations and give scientists the chance to recognize the instruments, services, and consumables that have made the biggest impact in their labs.
More expert interviews:
- Transform your pharmaceutical workflow with cutting-edge chromatography data management: Scientists around the world discuss the chromatography data system streamlining QC and QA workflows.Read article>>
- Targeting protein-protein interactions (PPIs): Identifying PPI inhibitors for novel therapeutics: Dr. David Andrews, AstraZeneca, discusses the future of small-molecule drug discovery for PPIs. Read article>>
- How AI is advancing neurodegenerative disease research: Guest editors Dr. Matthias Fassler, Genedata, and Daniel O’Connor, Molecular Devices, take a look at how the combination of automated imaging and deep learning is addressing research challenges and highlight how this approach helps accelerate drug development. Read article>>
- Clinical proteomics: Identifying biomarkers to predict patient risk of COVID-19: Learn how Radboud University Medical Center researchers have identified protein biomarkers linked to COVID-19 infection. Read article>>
- Instrumentation specialist shares secrets to flow cytometry success in a shared resource lab: Discover how the Bauer Core provides high-resolution and full-spectral flow cytometry data to life sciences researchers. Read article>>
- PARP inhibitors: A new frontier in the battle against cervical cancer: Dr. Santu Saha describes his team’s groundbreaking work to develop improved cancer treatments to avoid the potential side effects of chemotherapy.Read article>>
- The quest for precision medicine: Decoding cancer pathogenesis and overcoming drug resistance: Dr. Komal Kumar Javarappa shares insights from the multidisciplinary forefront of immuno-oncology, where translational biologists race against time to optimize new cancer therapies.Read article>>
- The rise of proteomics in advancing drug discovery and human health: Learn how the latest proteomics technology is driving large-scale, high-throughput studies in disease biology. Read article>>
- Incubation monitoring for cancer cell line quality control and banking: Find out how experts at the Ellison Institute are harnessing new cell monitoring technology to build cancer cell biobanks and enhance cell line quality control and authentication. Read article>>
Watch scientists at the forefront of drug discovery:
- Supporting science: Discover the technology enabling innovation communities in bioscience: Susie Harborth, Executive Vice President at Breakthrough Properties, explains how her company is delivering high-quality resources and environments that enable scientists to develop pioneering therapies, diagnostics, and vaccinations. Watch here>>
- Rare disease: How miniaturized immunoassays are advancing therapeutic development: Mark Dysinger, Developmental Scientist III, Bioanalytical Development, Alexion Pharmaceuticals, describes how miniaturized immunoassays enable accurate analysis of drug-target engagement. Watch here>>
- The magic behind conjugate vaccine development: Dr. Andrew Lees, CEO and Scientific Director of Fina Biosolutions, explains how the company has grown to offer a variety of bioconjugation and protein services.Watch here>>
- Photodynamic treatment of cancer: Dr. Theodossis Theodossiou discusses his team’s cutting-edge research into curing cancer with photodynamic therapy (PDT). Watch here>>
- Trends in drug discovery from SLAS2020: From cellular target engagement technologies to AI disrupting pharmaceutical developments: Melanie Leveridge, SLAS2020 Co-Chair and Head of Screening, Profiling & Mechanistic Biology, GSK (UK), explores the hot drug discovery trends at SLAS2020, including artificial intelligence and cellular target engagement technologies for the progression of drug discovery projects.Watch here>>
- Merck scientists present: dragonfly dispensing in drug discovery: Merck scientists Tina Minnick and Dr. Liudmila Dzhekieva share examples of how they have used the dragonfly discovery liquid handler from SPT Labtech in various drug discovery settings. Watch here>>
- Trends in drug discovery: New technologies, AstraZeneca’s approach and ELRIG event highlights: Steve Rees, Vice President Discovery Biology at AstraZeneca and Chair of ELRIG, discusses the latest technologies and techniques advancing drug discovery, including CRISPR, cryo-electron microscopy, PROTACS, artificial intelligence and machine learning. Watch here>>
Expand your drug discovery research skills with these top resources:
- How to Buy Microplate Readers: Here, we guide you through buying a new microplate reader by providing expert insight and all the information you should consider to select the best technology for your lab. Download eBook>>
- How to Buy Liquid Handling Technology: Expert insight and the information you should consider to select the best pipettes or automated liquid handling systems. Download eBook>>
- How to Buy Cell Imaging Technology: Find useful resources to help simplify your choice when it comes to purchasing your next cell imager.Download eBook>>
- How to Buy Flow Cytometers for Screening: Discover key factors and important considerations that can help guide your choice of flow cytometer for drug discovery and screening applications.Download here>>
- How to Buy Biophysical Characterization Technology: Take an in-depth look at biophysical methods for protein characterization including surface plasmon resonance (SPR), biolayer interferometry (BLI), isothermal titration calorimetry (ITC), microscale thermophoresis (MST), and microfluidic diffusional sizing (MDS).Download eBook>>
- How to Buy LC-MS Technology for Life Sciences: Discover the key factors and application considerations when looking to buy LC-MS technology, from sample prep to the latest LC-MS system.Download eBook>>
- How to Buy a UV/Vis Spectrophotometer: Here, we present a guide to all the key considerations to help you purchase the best UV/Vis technology to meet your lab’s needs. Download eBook>>
- Advances in CRISPR-Cas9 gene editing and screening technology: This eBook details a number of applications for gene editing and functional genomics screening using Horizon Discovery’s Edit-R™ CRISPR genome engineering platform.Download eBook>>
- High-content imaging for diverse 3D cell culture models: Learn how to capture in-depth and high-quality images of spheroids, stem cells, organs-on-chips and whole organisms, and read case studies from the scientists developing 3D cell assays to delve into the complex biology of neurodegenerative disease, angiogenesis and tumor microenvironment.Download eBook>>
- PCR/microplate sealing and peeling for high-throughput labs: Explore the key benefits of automating PCR, assay and compound storage plate sealing and peeling for medium to high-throughput laboratories, from reducing cross-contamination and reagent costs to freeing up scientist time and mitigating risk of repetitive strain injury. Download eBook>>
Your recommendations
Take a look at what other researchers and scientists all over the world are saying about the latest equipment and technologies in drug discovery. Logie Pillai, Viatris, shared his opinion on the Mastersizer 3000 by Malvern Panalytical:
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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.Compound LibrariesCompound libraries, or chemical libraries, are used in drug discovery for the identification of potential therapeutics compounds. Used in conjunction with high-throughput screening, the libraries of stored compounds are often generated for specific purposes as a drug target or disease model. Cheminformatics are commonly used when designing a compound library and software can be used to analyze the screening process. Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DosageDosage is the size or frequency of the administration of a drug. Determination of the dosage of a drug is critical in pharmaceutical development to ensure the optimum balance between efficacy and toxicity.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.TherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.Drug MetabolismDrug metabolism is the enzymatic conversion within the body of pharmaceutical substances into other chemical compounds. The primary site for drug metabolism is the liver.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Drug Discovery & Development Screening