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Addition to Specialist Protein Analyser to Assist in Immunological Disorder Investigation

11 Oct 2010
Sarah Sarah
Marketing / Sales

Product news

Three new complement assays have been added to the menu on the SPAPLUS Specialist Protein Analyser: C3c, C4 and CH50. These assays are fully automated, easy to use and provide quantitative results for total complement activity plus levels of C3c and C4 to aid the investigation of immunological disorders. especially those associated with deficiencies of complement components (US customers should contact us regarding diagnostic use of the CH50 assay).

C3c and C4 assays are provided as 100 test complete kits including calibrators for a 6 point curve. Reagents have long shelf life and long open vial stability for batch consistency and improved result accuracy.

The CH50 SPAPLUS assay for quantitation of total complement activity in human serum can be used as a screening assay for functional complement. This fully automated assay is ideal for higher workloads, increasing sample throughput and reducing turnaround times. The CH50 200 test kit is complemented by a set of 6 calibrators to produce a 6 point curve, plus controls. Results are quantitative and non-subjective and the assay utilises long shelf-life reagents to provide kit stability and batch consistency. The liposome technology used employs the traditional lysis methodology and has shown good agreement with the CH50 tube test method.

These additions complement the panel of assays currently available on SPAPLUS which include IgG, IgA, IgM, IgD, IgG subclasses and IgA subclasses, FreeliteTM serum free light chain assays, HevyliteTM IgA kappa and IgA lambda assays and Cystatin C.

Binding Site has a wide range of other assays available for measuring complement activity and quantifying individual components of the complement cascade as an aid in the investigation of primary immunodeficiencies.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Robotic InstrumentsRobotic instruments can be used for high-throughput automation of many lab processes. Such processes use instruments for assays like cell based assays and ELISA, for sample preparation like shakers, centrifuges and incubators, and for analysis such as sequencing and western blot analyzers. Useful features of robotic instruments include speed, reproducibility, barcode readers, software and automation.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.

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Addition to Specialist Protein Analyser to Assist in Immunological Disorder Investigation