ADDA High-Speed Dual Arm Autosampling System

25 May 2011
bridget bridget
Laboratory Director

Product news

The ADDA system is a dual-arm, high-speed autosampler that provides ADME discovery scientists with the fastest high-quality sample delivery platform available for LC/MS. At 8 seconds per sample in trap/elute mode, and with 8 unique injection ports, the ADDA system is a comprehensive system designed for the Discovery lab.

With the ADDA system, permeability, transport, metabolic stability and drug-drug interaction screening assays can be rapidly turned around with a single mass spectrometer system, saving critical time in the drug discovery process.

The system achieves its speed and flexibility with 2 high-speed, high-accuracy robotic arms, each equipped with a syringe and four injection ports. Batches can be submitted to use either one arm or both arms simultaneously. The plumbing can be set up on a per-injection-port basis, allowing up to 8 different gradients and columns to be left on the system. Four onboard valves simplify the plumbing for the system. Testing with multiple chromatographic setups, direct infusion and high-speed trap and elute experiments can be performed in a completely automated fashion. The ADDA system represents a significant leap forward in both speed and cost savings within high throughput drug discovery.

Tags

High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Robotic WorkstationsRobotic workstations are automated platforms enabling the user to perform high-throughput, multi-application processes, from sample preparation tasks such as PCR set-up, DNA purification and NGS library preparation, to integrated sample prep and analysis workstations. Automation makes processes consistent, fast, precise and fully walk-away. Find the best robotic workstations in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.