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A systems-level approach to understanding the immunology of COVID-19 in adults and children

SelectScience
4 Oct 2020
Edward Carter
Publishing / Media

Expert insights

Dr. Petter Brodin, Director at SciLifeLab Mass Cytometry Facility

This webinar will present recent studies from Dr. Petter Brodin's group at Karolinska Institute in Stockholm that provide important new insights into the immune system responses to SARS-CoV-2 infection. These studies took a systems-level approach to analyze both the cellular and protein components involved, using methodologies including mass cytometry, flow cytometry and high-multiplex proteomics.

A longitudinal study of severe COVID-19 patients identified distinct patterns of immune cell coregulation in four different stages of the disease and demonstrated a shared trajectory of immunological recovery that may provide future biomarkers of disease progression. In an investigation of Multisystem Inflammatory Syndrome in Children (MIS-C), a relatively rare complication of SARS-CoV-2 infection in children, important differences in inflammatory response were seen between MIS-C and severe COVID-19 in adults. Moreover, while some similarities were observed between inflammatory responses in MIS-C and Kawasaki disease, important differences were also apparent, particularly in the T-cell subsets involved.

Register here

Key Learning Objectives

  • Observe how a systems-level approach combining multiple methodologies can provide essential insights into complex biological questions such as immune responses
  • See the impact of combining cellular and molecular analyses in trying to better understand the intricate and varied immune system responses in COVID-19
  • Learn how protein biomarkers can contribute to a deeper understanding of the pathophysiology of COVID-19 and facilitate future treatment strategies

Who Should Attend

  • Molecular or cell biologists, clinicians or scientists in the pharmaceutical industry who have an interest in COVID-19, or more broadly in the human immune system

Certificate of attendance

All webinar participants can download a certificate of attendance for continuing education purposes from the webinar auditorium’s resources section.

This webinar will run on Wednesday, October 21, at:

  • 16:00 BST
  • 17:00 CEST
  • 11:00 EDT
  • 08:00 PDT

Register for this webinar here>>

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ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.ImmunologyImmunology is the branch of medical science that covers the study of all aspects of the immune system of multicellular organisms.Flow CytometryCoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.MultiplexingMultiplexing refers to the ability to measure multiple targets or analytes simultaneously in a single experiment. This technique is valuable for high-throughput screening, diagnostics, and complex assays, as it increases efficiency and data quality. Browse our peer-reviewed product directory to find the best multiplexing products, compare tools, check reviews, and get pricing directly from manufacturers.

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A systems-level approach to understanding the immunology of COVID-19 in adults and children