‘A scientific discovery is only as good as its communication’

Meet this week’s Reviewer in the Spotlight, Dr. Noelle Cutter, a humanitarian who loves helping people whether it’s patients, students, or scientific peers through her reviews

25 Apr 2023
Diane Li
Assistant Editor

Editorial article

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Dr. Noelle Cutter, Molloy College
Dr. Noelle Cutter is an associate professor and director of the First Year Experience at New York's Molloy College

Lab product reviews can change the world by helping other scientists find the best equipment to accelerate their vital work. Here at SelectScience, we are dedicated to promoting peer-to-peer communication that will make the difference - but we couldn't do it without our esteemed reviewers. In this regular new feature, we put the spotlight on some of our most dedicated and impactful reviewers and find out what inspires them to keep sharing their knowledge with the global scientific community.

For this week’s ‘Reviewer in the Spotlight’, we speak with Dr. Noelle Cutter, associate professor at New York’s Molloy College, whose drive to shape a better world is shown in her passionate approach when it comes to working with cancer patients and educating the young minds of future scientists. Here, Noelle tells us about her research, the importance of effective communication in science and reveals her motivations behind writing SelectScience reviews.

Tell us about your role and what your research focuses on

I am an associate professor and director of the First Year Experience at Molloy College. By training, I am a scientist in the field of immunology where I have dedicated my career to studying immunotherapy options for pediatric patients diagnosed with a rare and aggressive form of brain cancer known as medulloblastoma.

I like to think that I take a unique and passionate approach to working with patients. Cancer remains the most common cause of death due to disease in children. Over the past decade, researchers have made great strides in understanding cancer but finding cures has still been difficult. In an ever-changing world, sometimes a new approach to solving this problem is necessary. Our students are transforming the viewpoint in society by setting a local example through their teamwork approach in solving problems. It is collaboration like this that will be needed to solve some of the world’s larger crises, like cancer. I am most interested in the role that methylation plays in gene regulation allowing tumors to grow and divide. By doing so, I hope to be able to better diagnose patients so they can be treated more efficiently.

Dr. Noelle Cutter Microscope
Dr. Cutter is working with science advocates in New York to help in the distribution of the COVID-19 vaccine

What's been your experience with the COVID-19 pandemic?

During the COVID-19 pandemic, I worked in an antibody testing lab where I helped design synthetic peptides to test for the presence of SARS-Cov2 antibody in patient serum. Our work on the ELISA testing plate was implemented in numerous labs across New York and Colorado. My collaboration in this platform was one of the first successful testing options for the novel 2019 coronavirus. I now continue my efforts working alongside science advocates on Long Island to help in the distribution of the COVID-19 vaccine, as part of #vaccinateNYS. The goal is to make sure the distribution is fair and equitable to the general public.


What inspired you to get into the world of science?

I think at heart I am a humanitarian. I was always driven by service to others. I’ve been interested in various aspects of science as early as I can remember. I like that scientists are trying to find answers to many difficult questions. Finding answers is what I am passionate about, especially when it means I can help patients.

This really hit home when my nephew Louie was diagnosed with brain cancer at only 16 months old. He lost his battle to medulloblastoma in six weeks. I witnessed firsthand what this disease can do to someone. No one should have to endure that, especially a child.

Why do you think communication is vital in science?

Scientific discovery is only as good as its communication; the key is to accommodate the multiple communication paths from that discovery. Scientists doing the work can see more connections themselves when they organize data in a different way. Colleagues will more easily replicate experiments. Scientific writing can often get clogged up with technical details and confusing jargon; scientists transfer that knowledge with the hopes of reaching people, but those people can have trouble understanding what it all means. When context is not available, connections are missed, and critical discoveries may remain hidden.

We need to do better, and we need to trust science again. That can only be achieved if the science is communicated clearly, efficiently, and contextually.

  

Dr. Cutter, SelectScience Life Sciences Reviewer of the Year for 2021, explains how lab product reviews help scientists make better-informed decisions

What is your favorite piece of lab equipment?

We were very lucky to receive a grant from the National Science Foundation to purchase a plate reader, the Molecular Devices SpectraMax multi-mode microplate reader. It is truly an amazing piece of equipment. For someone who is constantly running ELISA assays, this instrument has allowed for both high-performance and assay flexibility.

Noelle Cutter Review

Why do you think lab equipment reviews are important and how do they help you with your research?

As a scientist in the lab, we are always looking for the latest reagents, kits, and equipment that will help our science grow. SelectScience reviews are incredibly useful. Knowing that someone has tried the item is so helpful in determining if this item will help in our own scientific discovery. Just as reviews for local restaurants are so important, scientific reviews on lab equipment help us be assured that what we purchase will be useful for our own important research.

SelectScience product reviews have provided a firsthand, unbiased, and complete product experience shared by other scientists and lab professionals. I have written several reviews because I know the importance that my input makes to others who are looking to buy the same items.

What would you like to achieve in your work?

In the years that I’ve spent doing cancer research, I find there is a reason for hope because research leads to cures. My students have given me that hope. Our students have transformation at the heart of their work and mindset, connecting our major initiatives to locally-driven movements and globally set milestones. This next generation will explore their differences and identify new possibilities for collaboration as they re-imagine the world in which we live to make it better for our future generations. Cancer continues to be a fatal disease in pediatric patients. It seems self-evident that if we are to make an impact on the patients, we must begin to understand the disease more completely. Being a professor has taught me that, not just in my lab, but globally, we have unique resources in academia with our next generation of students for basic science research that transcends borders.

If there is one thing I've learned in my 12 years studying cancer, it’s that our students have a drive of service to others. I want to thank them for their participation, collaboration, and most of all, for their confidence in our ideas. They have put their trust in us to educate them. At their core is the drive to shape a better world. This will not change, even as most everything else does. They truly are the recipe for transformation.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Gene RegulationReviews