A Novel Microfluidic Device for Advanced Cell Immobilization and Observation

Dolomite in collaboration with The Gurdon Institute (University of Cambridge), has introduced the Embryo Immobilisation Chip ideal for the immobilization and observation of embryos or cell aggregates of up to 150μm in diameter.

Historically, live imaging of a large number of small non-adherent samples, for a long time and at high-resolution, has been very difficult to achieve due to movements of the sample during handling processes. Working closely with Bernhard Stauss and The Gurdon Institute, Dolomite has addressed these challenges by developing a novel glass microfluidic device, optimized for high-resolution imaging and high throughput experimentation.

Featuring over 250 well chambers, the Embryo Immobilisation Chip keeps samples in position throughout imaging as well as during mounting from the microscope, allowing observations to be carried out over a number of days. Once viewing is complete, users can easily retrieve samples from the device for further analysis, including fixation, staining or genotyping.

The microfluidic chip can be supplied with a Chip Interface which is compatible with a wide range of standard microscope stage inserts. Offering excellent chemical compatibility and access for optics, the Embryo Immobilisation Chip and Interface enable users to quickly locate and observe the area of interest.

For further information on Dolomite’s range of microfluidic chips as well as a complete portfolio of microfluidic products including chips, connectors/ interconnects, valves and custom devices please visit the company article page.