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A Novel Dynamic Delivery System Enabling High Efficiency Transfection of Cells

Mirus Bio LLC
9 Oct 2013
Sarah Thomas
Associate Editor

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This poster evaluates the TransIT-X2™ Dynamic Delivery System, a novel, non-liposomal polymeric delivery system designed to facilitate high efficiency and functional delivery of plasmid DNA and/or siRNA. An extensive head-to head comparison with a popular liposomal reagent is described and functional co-delivery of plasmid DNA and siRNA and functional delivery of siRNA and miRNA are assessed to demonstrate dual abilities of this system.

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TransIT-X2™ Dynamic Delivery System

Mirus Bio LLC

An innovative, polymeric system for efficient delivery of plasmid DNA and siRNA/miRNA. Experience the transfection breakthrough. Achieve superior transfections with an innovative polymeric system that efficiently delivers both DNA and RNA out of the endosome and into the cytoplasm overcoming a critical barrier to nucleic acid delivery.Head-to-head comparisons against the Lipofectamine® 2000 illustrate superior or equal luciferase expression using TransIT-X2 in 26 of 30 cell types; 11 cell types had expression levels 2-fold higher than Lipofectamine 2000.TransIT-X2™ Dynamic Delivery System Features: Efficiency - Exceptional Broad Spectrum Transfection Versatility - Cutting Edge Delivery of Plasmid DNA and siRNA Technology - Novel, Non-Liposomal, Polymeric Delivery

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.TransfectionTransfection introduces nucleic acids (DNA or RNA) into cells, facilitating gene expression, genome editing, and functional studies. It�s widely used in genetic research, drug discovery, and therapeutic development. Find transfection reagents, kits, and systems in our product directory with reviews and pricing options.

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