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A new instrument for luminescence immunoassay, the CentroLIA<i>pc</i> - introducing the next generation of clinical luminometers

BERTHOLD TECHNOLOGIES GmbH & Co. KG
17 Nov 2007

Product news

BERTHOLD TECHNOLOGIES introduces a new plate luminometer for Luminescence immunoassay. As an increasing number of Clinical Laboratories are switching from traditional RIA and ELISA methods to luminescence assays (LIA) Berthold has introduced a second plate luminometer specifically for this application.

The CentroLIA is already established as an excellent instrument for the measurement of LIA kits in the Clinical Laboratory offering full immunoassay data reduction without the need for a PC. The simple intuitive software dialog allows the user to be up and running within minutes and provides full graphic curve printouts for all types of LIA.

As the price per test of the LIA kits becomes more and more attractive compared to the ELISA as-says and the benefits of increased sensitivity, wider dynamic range and shorter incubation times the demand for dedicated clinical instruments is increasing.

To complement the CentroLIA Berthold has introduced the CentroLIApc LB 962 which offers a PC driven instrument with an extremely intuitive software dedicated to the Clinical Laboratory. Berthold has taken great care to provide a software that is easy to set up for each assay kit. OEM customers can request instruments to be shipped with all the kit parameter pre defined in the factory.

The CentroLIApc also addresses the need for more competitive pricing where the price per test is the all important feature. The quality and performance is of course of the highest order in line with the enviable reputation of Berthold. The instrument is primarily aimed at the OEM market with the LIA kit companies and Berthold welcomes enquiries from any interested kit manufacturers.

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ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.

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