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A LoGiCal® success at Analytical Services International

LGC Standards
24 May 2012

Product news

Analytical Services International (ASI) at St George’s, University of London, UK, has been evaluating LoGiCal certified reference materials – a new product range from LGC Standards – for its therapeutic drug monitoring (TDM) services, where high quality reference standards are an essential requirement.

The use of high quality reference materials is equally important for the Company’s international proficiency testing scheme for immunosuppressive drugs, co-ordinated by Professor David Holt. ASI recently validated the use of LoGiCal solutions of the immunosuppressant mycophenolic acid (MPA) and antiarrhythmic amiodarone metabolite desethylamiodarone (DEA) in its assays.

Michelle Moreton-Clack, TDM Service Manager, explained: “As part of our therapeutic drug monitoring service, we run assays for the measurement of MPA and DEA. We usually buy the drugs in powder form and weigh them out to prepare stock solutions for our assays. The LoGiCal range includes ISO Guide 34 certified solutions of MPA and DEA, which are really easy to use and save a lot of time by eliminating weighing stages. We validated both compounds against our existing stock solutions, and they showed good correlation; I am very pleased with the results.”

To learn more about the LoGiCal product range, visit www.LoGiCal-Standards.com

To learn more about TDM at Analytical Services International, visit www.bioanalytics.co.uk/routine_assays.html

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Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Therapeutic Drug MonitoringMycophenolic AcidDEADrug MetabolismDrug metabolism is the enzymatic conversion within the body of pharmaceutical substances into other chemical compounds. The primary site for drug metabolism is the liver.

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A LoGiCal® success at Analytical Services International