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A high-throughput test for neutralizing antibodies to SARS-CoV-2 as alternative to live virus neutralization and immunoglobulin detection

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Join this webinar to find out how scientists are detecting the antibodies blocking viral entry into the cell

23 Jun 2020
Sophie Ball
Publishing / Media

Expert insights

Sean Taylor, Manager of the Field Applications Group, GenScript USA, Inc

The need for a reliable supply of accurate serology tests is paramount as countries globally have started opening their economies since the onset of the COVID-19 pandemic. Most ELISA-based serological tests for SARS-CoV-2 utilize either protein (typically receptor-binding domain (RBD) or truncations of the spike protein and/or nucleocapsid) or antibody (anti-IgG or anti-IgM) coated plates for capture and detection of IgG and/or IgM.

Even more important than just detecting antibodies is the ability to detect the antibodies blocking the virus entry into the cell. The newly developed cPass™ Neutralization Antibody Detection kit utilizes the interaction between RBD and the human ACE2 receptor to provide greatly improved speed, scalability and ease-of-use compared to the gold standard virus neutralization assay. Since it uses soluble RBD for detection, the assay is also isotype and species independent for highly specific and sensitive immunoglobulin detection across animal models and human samples.

Register Now

Join our upcoming webinar covering:

  • An overview of pre-existing serological tests for SARS-CoV-2
  • Why sample timing and sample handling is important for high-quality, accurate data
  • Description of a new neutralization assay test that is immunoglobulin agnostic and species independent for increased sensitivity and specificity
  • The elucidation of functional antibodies that block the binding of RBD to human ACE2 receptor as a unique benefit of the neutralization assay

Who Should Attend?

  • Clinical diagnostics labs interested in fast and accurate tests for COVID-19 immunity
  • Vaccine and drug development groups who not only require the measurement of an immune response to vaccination but also need functional antibodies that block the interaction between RBD and ACE2 receptor in small animal models and human samples
  • Basic research labs studying small molecule, antibody or peptide interactions with RBD as a means of inhibiting its interaction with ACE2

The live webinar takes place on Monday, July 6, 2020, at:

  • 14:00 BST
  • 15:00 CEST
  • 09:00 EDT
  • 06:00 PDT

Register to watch the full webinar here>>

SelectScience runs 3-4 webinars a month across various scientific topics, discover more of our upcoming webinars>>

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Antibody PurificationVirusesViruses are microscopic pathogens that require a host cell to replicate. Understanding their structure, replication cycle, and impact on the immune system is crucial in developing effective treatments, vaccines, and diagnostic methods. Research continues to focus on emerging viral diseases and antiviral drug discovery. Explore solutions for virus research, detection, and treatment in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.CoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.Covid-19COVID-19, caused by the SARS-CoV-2 virus, has led to a global health crisis with profound impacts on societies and economies. Research into diagnostics, vaccines, treatments, and understanding viral mechanisms continues to evolve. The pandemic has accelerated innovations in healthcare and biopharmaceuticals, including novel vaccine platforms and rapid testing technologies. Browse our peer-reviewed product directory to find top COVID-19 testing kits, research tools, vaccines, and treatments, compare products, read reviews, and receive direct pricing from manufacturers.

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