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842 Titrando - pH STAT Titrator and Organic Synthesis Controller... ideal for chemists in the biotech and pharmaceutical industries

17 May 2006
Kerry Parker
CEO

Product news

The 842 Titrando expands a Metrohm Potentiometric Titration system by adding the modes pH STAT titration and controlled dosing.

STAT titration

The determination of the activity of an enzyme or the monitoring of the release kinetics of antacid drugs requires a titrator that rapidly adjusts a predefined pH value and keeps it constant over a long time period. The 842 Titrando's controller has been optimized for this task and is among the best available on the market. Tandem dosing is a new feature offered by the 842 Titrando. To avoid a break in dosing when the buret is refilled, a second buret takes over the dosing operation without any interruption. This means that fast reactions and those that have a high reagent consumption can be monitored without any loss of accuracy.

Controlled dosing

The tasks to be performed in the synthesis laboratory differ from those in titration. Typical synthesis work involves maintaining constant a pH value or performing a multiple dosing operation under strictly defined conditions: A preset volume has to be added to a solution during a given time span. During the controlled dosing procedure, the parameters pH (or potential) and temperature are continuously monitored and registered. This results in a complete documentation of the synthesis sequence. Dosing can also be carried out continuously in the tandem mode with two Dosinos.

A new feature of the 842 Titrando is its ability to perform control tasks. External instruments can be controlled by means of freely programmable TTL signals or by communication via RS 232 interface. This opens up the possibility of remotely controlling external heating or cooling apparatus, pumps or similar devices. The 842 Titrando is compatible with PC Control 4.0, the latest firmware versions of 808, 809 und 840 Touch Control and tiamo 1.1.

For further information please contact Metrohm UK Ltd, Tel 01280824824, Fax 01280824800, email enquiry@metrohm.co.uk

Tags

Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.

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842 Titrando - pH STAT Titrator and Organic Synthesis Controller... ideal for chemists in the biotech and pharmaceutical industries