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8 Recent Advances in Bio Imaging and Microscopy

SelectScience

Discover the latest products and methods for the imaging of biological samples

31 Aug 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Editorial article

Discover the latest methods and products for imaging biological samples

1. APPLICATION NOTE: Multiple Images from a Single Tissue Section with Dual Polarity Desorption Electrospray Ionization MS

Learn how DESI imaging using Waters' SYNAPT® G2-Si HDMS Mass Spectrometer enables sequential analysis of a single tissue section for comprehensive molecular profiling. Mass spec imaging of tissue sections was accomplished using a SYNAPT® G2-Si HDMS Mass Spectrometer equipped with a 2D-DESI source, and data was generated and analyzed using HDI Software v1.3. Download method.

2. PRODUCT: Solutions for the Visualization and Analysis of Big Image Data in Life Sciences

New microscopy technologies, such as light sheet fluorescence microscopy (LSFM) or clearing methods, allow the imaging of large samples at high resolution or high frame rates. ZEISS has teamed up with arivis AG to offer complete solutions, from initial image acquisition to final results, to overcome common challenges in handling, processing, and analyzing multi-terabyte data sets. Learn more.

3. PRODUCT: Unmatched Optics, Laser Control and Accuracy from Expanded Olympus cellTIRF Family

The recently expanded Olympus cellTIRF family represents the latest technology in advanced TIRF solutions, providing a series of features for precise imaging with effortless control. By matching quality optics with high-end motorized TIRF devices, Olympus offers a system that enables easy access to super-resolution microscopy, performed using single-molecule localization techniques. Read more.

4. WEBINAR: Quantification of NF-ĸB Signaling in Living Cells using the Operetta High Content Imaging System

Discover how PerkinElmer’s Operetta® High Content Imaging System can be used to study the dynamics of the NF-ĸB family of transcription factors, pivotal in immunity and cell response, in living cells. NF-ĸB signaling is an attractive target in the development of drugs against inflammation-related diseases. Watch on-demand.

5. APPLICATION NOTE: Lumenera’s Scientific-Grade Cameras Offer Imaging Solutions for Growing Digital Pathology Market

Pathology is intricately connected to all medical advancements, as the study and diagnosis of disease through examination of organs, tissues, and bodily fluids. While microscopes still hold a central role in this science, digital pathology stands as an equally critical evolution in this field. Digital pathology is the practice of digitizing glass slides and managing the resultant information for later educational, diagnostic, and analytic purposes. In this application note, the use of Lumenera’s scientific grade cameras in digital pathology applications is explored. Download method.

6. VIDEO: Improved Imaging of Large Cleared Samples with ZEISS Lightsheet Z.1

Tissue clearing allows you to image deep into large biological samples such as tissue sections, brains, embryos, organs, spheroids or biopsies. Light sheet fluorescence microscopy (LSFM) enables imaging of cleared specimens with exceptional light efficiency, speed and next to no photo damage. Watch this video to learn how to mount cleared samples in ZEISS Lightsheet Z.1. Watch video.

7. ARTICLE: My Lab Essentials: Why UV isn't the Enemy

In the latest interview in our Lab Essentials series, Dr Richard Weller, Senior Lecturer in Dermatology at the University of Edinburgh, explains the effect of sunlight on the cardiovascular system, how we could be doing more harm than good by avoiding the sun in the name of health, and how microscopy is essential in his research. Read more.

8. BUYING GUIDE: Download the New Microscopy Buying Guide Now!

New microscopy techniques are continually developing as solutions to imaging problems. If you are looking to invest in microscopy equipment, this essential SelectScience Buying Guide provides you with all the information you need to help you to make the right decision, based on your requirements. Download now.

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Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Digital MicroscopyDigital microscopy involves using digital cameras and sensors to capture high-resolution images of samples for analysis. It offers enhanced imaging capabilities compared to traditional optical microscopy and is widely used in biological and material science research. Explore digital microscopy systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Tissue ProcessingTissue processing involves preparing biological tissue samples for microscopic analysis, including fixation, embedding, and sectioning. This process is essential for histopathology and diagnostic applications. Explore tissue processing products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Digital PathologyDigital pathology involves the use of digital imaging and computational tools to analyze pathology slides. It is transforming diagnostics, research, and education by offering enhanced image storage and analysis. Explore digital pathology solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.MicroscopyMicroscopy is a technique used to observe small objects in detail, from cells to materials, using light or electron microscopes. It enables researchers to examine structures with high resolution, aiding in fields such as biology, medicine, and materials science. With advanced microscopy techniques, scientists can gain insights into cellular processes, tissue structures, and material properties. Explore the best microscopy solutions in our peer-reviewed product directory, compare products, read customer reviews, and get pricing directly from manufacturers.

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