10X Genomics Commences Shipments of the GemCode Platform

Commercial adoption of long range information with short read sequencing

30 Jun 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

10X Genomics announces the full commercial release and availability of the GemCode Platform with instrument shipments and installations actively underway. Announced at AGBT 2015 in February, the GemCode Platform is a unique molecular barcoding and analysis platform that consists of instrumentation, reagents and software, which delivers long-range information, including haplotype phasing, structural variation, and other critical genomic information. By upgrading existing short read sequencers the GemCode Platform generates a powerful new data type: Linked-Reads.

“Broad researchers are excited to start generating 10X data,” said Stacey Gabriel, Director, Genomics Platform at the Broad Institute. “With the GemCode Platform now installed, we will soon deliver Linked-Reads for a range of applications including structural variant detection and haplotype phasing. This technology will be a great addition to the suite of sequencing offerings we make available to the scientific community.”

The GemCode Platform partitions arbitrarily long DNA molecules (including > 100kb) and prepares sequencing libraries in parallel, so that all fragments produced within a partition share a common barcode. A simple workflow combines large partition numbers with a massively diverse barcode library to generate >100,000 barcode containing partitions, while only requiring ~ 1ng of DNA input.

“10X Genomics is enabling researchers to routinely access genomic information that was previously difficult or impossible to obtain,” said Serge Saxonov, CEO of 10X Genomics. “At AGBT, we committed to commercial shipments of the GemCode Platform in the second quarter of this year, and are very pleased to have met that goal with shipments to multiple customers. We are well on our way to changing the definition of sequencing.”

Links

Tags

DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.Genome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Genome EditingGenome editing involves altering the DNA of an organism, which holds promise for disease treatment, agriculture, and gene therapy. Techniques like CRISPR-Cas9 are revolutionizing this field, enabling precise genetic modifications. Explore genome editing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.DNA BarcodingDNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.Library GenerationLibrary generation refers to the construction of NGS libraries from RNA and DNA sources.